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ACINIC-CELL

*********************************************************************** Topics** MEDICAL Default-Topics** ALL *********************************************************************** HISTORY: 9/19/99 - Create List - gfrydman@acor.org (gjf) Add initial owner: gfrydman@acor.org ******************************************************************** ******************************************************************** *********************************************************************** WHAT IS ACINIC CELL CARCINOMA? ------------------------------ Acinic or Acinar Cell Carcinoma is a rare salivary gland cancer, comprising approx. 4% of all minor, and 2-4% of all major salivary gland tumors. They account for approx. 13% of all malignancies of the parotid gland, and are rarely seen in other salivary tissues. One will occasionally find an equally rare acinic/acinar cell carcinoma of the pancreas. Acinic Cell Tumors are typically slow-growing,low-grade (highly differentiated) neoplasms that appear in all age groups, but are most common in women. Although indolent in nature (slow-growing), they are also quite insidious in their preponderance for local recurrences and distant metastases, often MANY years later. Local and multiple recurrences may occur in up to half of patients. Recurrences and metastases 5-10 years after inadequate primary tumor removal are common, and occurrences 25-30 years after initial treatment are noted. The most common sites of metastases are lungs and bone. Also noted are central nervous system, mediastinum (space in the chest between the pleural sacs of the lungs) liver and brain. Lymph node metastases occur in only 16% of patients. The high grade variants are very uncommon and associated with much poorer survival. However, overall, many authors consider Acinic Cell Carcinoma patients to have the most favorable outlook of all salivary gland patients, with survivals of 80-85% at 10 years. Acinic Cell belongs to the family of Adenocarcinomas. Cancers with some similarities include Adenoid Cystic, Muco-Epidermoid, Low-grade Adenocarcinomas, and possibly some Breast Cancers. Due to the rare nature of this cancer, treatment results are often anecdotal. Historically, treatment involves various levels of surgery, often with post-operative radiation. In recent years, radiation treatment alone, specifically with fast-neutron beam radiation, has shown promising and effective results, especially for inoperable tumors. Chemotherapy has largely been ineffective, except for pain-relief, or partial responses. Surgery and Radiation results have proven most successful with smaller early-stage tumors. Radiation results with larger tumors are often not curative. Exploration of clinical trials and new protocols are suggested. ******************************************************************** ACIN-CELL is an unmoderated discussion list for parents, sibblings, friends, researchers, and physicians, to discuss clinical and nonclinical issues and advances pertaining to Adenoid Cystic Carcinomas. This includes patient experiences, psychosocial issues, new research, clinical trials, and discussions of current treatment practices. This list is part of a group of lists sponsored by ACOR, the Association of Cancer Online Resources (http://www.acor.org).

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